2018年

Kanaya, T., Sakakibara, S., Jinnohara, T., Hachisuka, M., Tachibana, N., Hidano , S., Kobayashi, T., Kimura, S., Iwanaga, T., Nakagawa, T., Katsuno, T., Kato, N., Akiyama, T., Sato, T., Williams, I. R., Ohno, H. Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF- kappa B signaling. J. Exp. Med. 215:501-519, 2018

2017年

Takayasu, L., Suda, W., Watanabe, E., Fukuda, S., Takanashi, K., Ohno, H., Takayasu, M., Takayasu, H., Hattori, M. A 3-dimensional mathematical model of microbial proliferation that generates the characteristic cumulative relative abundance distributions in gut microbiomes.PLoS ONE 12(8):e0180863, 2017

Lye HS, Kato T, Low WY, Taylor TD, Prakash T, Lew LC, Ohno H, *Liong MT. Lactobacillus fermentum FTDC 8312 combats hypercholesterolemia via alteration of gut microbiota. J. Biotechnol. 262: 75-83, 2017

Yanagihara S, Kanaya T, Fukuda S, Nakato G, Hanazato M, Wu XR, Yamamoto N, Ohno H. Uromodulin-SlpA binding dictates Lactobacillus acidophilus uptake by intestinal epithelial M cells. Int. Immunol. 29: 357-363, 2017

Nakajima A, Kaga N, Nakanishi Y, Ohno H, Miyamoto J, Kimura I, Hori S, Sasaki T, Hiramatsu K, Okumura K, Miyake S, Habu S, Watanabe S. Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice. J. Immunol. 199: 3516-3524, 2017

Date Y, Ebisawa M, Fukuda S, Shima H, Obata Y, Takahashi D, Kato T, Hanazato M, Nakato G, Williams IR, Hase K, Ohno H. NALT M cells are important for immune induction for the common mucosal immune system. Int. Immunol. 29: 471-478, 2017

Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shiba.ta, N, Williams, I. R., Kiyono, H., Ohno , H. IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake.　 J. Exp. Med. ;214(6):1607-1618 .2017（モデル図はこちら）

Shimokawa, C., Kanaya, T., Hachisuka, M., Ishiwata, K., Hisaeda, H., Kurashima, Y., Kiyono, H., Yoshimoto, T., Kaisho, T., Ohno, H. Mast cells are crucial for induction of group 2 innate lymphoid cells and clearance of helminth infections. Immunity 46(5):863-874.e4. 2017 （モデル図はこちら）

2016年

Kimura S, Yamashita M, Yamakami-Kimura M, Sato Y, Yamagata A, Kobashigawa Y, Inagaki F, Amada T, Hase K, Iwanaga T, Ohno H , Fukai S. Distinct Roles for the N- and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation. Sci Rep . 2016 Sep 15;6:33548. doi: 10.1038/srep33548.

Ohashi W, Kimura S, Iwanaga T, Furusawa Y, Irie T, Izumi H, Watanabe T, Hijikata A, Hara T, Ohara O, Koseki H, Sato T, Robine S, Mori H, Hattori Y, Watarai H, Mishima K, Ohno H , Hase K , Fukada T. Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress. PLoS Genet . 2016 Oct 13;12(10):e1006349. doi: 10.1371/journal.pgen.1006349. eCollection 2016 Oct.

Okai S, Usui F, Yokota S, Hori-I Y, Hasegawa M, Nakamura T, Kurosawa M, Okada S, Yamamoto K, Nishiyama E, Mori H, Yamada T, Kurokawa K, Matsumoto S, Nanno M, Naito T, Watanabe Y, Kato T, Miyauchi E, Ohno H , Shinkura R. High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice. Nat Microbiol . 2016 Jul 4;1(9):16103. doi: 10.1038/nmicrobiol.2016.103.

Yasuda T, Fukada T , Nishida K, Nakayama M, Matsuda M, Miura I, Dainichi T, Fukuda S, Kabashima K, Nakaoka S, Bin BH, Kubo M, Ohno H , Hasegawa T, Ohara O, Koseki H, Wakana S, Yoshida H. Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis. J Clin Invest . 2016 Jun 1;126(6):2064-76. doi: 10.1172/JCI82887. Epub 2016 Apr 25.

Matsuda Y, Kato T, Takahashi N, Nakajima M, Arimatsu K, Minagawa T, Sato K, Ohno H , Yamazaki K.Ligature-induced periodontitis in mice induces elevated levels of circulating interleukin-6 but shows only weak effects on adipose and liver tissues. J Periodontal Res . 2016 Oct;51(5):639-46. doi: 10.1111/jre.12344. Epub 2015 Dec 15.

Hayashi R, Tsuchiya K, Fukushima K, Horita N, Hibiya S, Kitagaki K, Negi M, Itoh E, Akashi T, Eishi Y, Okada E, Araki A, Ohtsuka K, Fukuda S , Ohno H , Okamoto R, Nakamura T, Tanaka S, Chayama K, Watanabe M. Reduced Human α-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease. Inflamm Bowel Dis . 2016 May;22(5):1119-28. doi: 10.1097/MIB.0000000000000707.

Nakato G, Hase K, Sato T, Kimura S, Sakakibara S, Sugiyama M, Obata Y, Hanazato M, Iwanaga T, Ohno H . Epithelium-Intrinsic MicroRNAs Contribute to Mucosal Immune Homeostasis by Promoting M-Cell Maturation. PLoS One . 2016 Mar 1;11(3):e0150379. doi: 10.1371/journal.pone.0150379. eCollection 2016.

Hashimoto M, Bhuyan F, Hiyoshi M, Noyori O, Nasser H, Miyazaki M, Saito T, Kondoh Y, Osada H, Kimura S, Hase K, Ohno H , Suzu S. Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages. J Immunol . 2016 Feb 15;196(4):1832-41. doi: 10.4049/jimmunol.1500845. Epub 2016 Jan 15.

2015年

Hurst LD, Ghanbarian AT, Forrest AR; FANTOM consortium., Huminiecki L. The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome. PLoS Biol . 2015 Dec 18;13(12):e1002315. doi: 10.1371/journal.pbio.1002315. eCollection 2015 Dec.

Carbajo D, Magi S, Itoh M, Kawaji H, Lassmann T, Arner E, Forrest AR, Carninci P, Hayashizaki Y, Daub CO; FANTOM consortium., Okada-Hatakeyama M, Mar JC. Application of Gene Expression Trajectories Initiated from ErbB Receptor Activation Highlights the Dynamics of Divergent Promoter Usage. PLoS One . 2015 Dec 14;10(12):e0144176. doi: 10.1371/journal.pone.0144176. eCollection 2015.

Atarashi K, Tanoue T, Ando M, Kamada N, Nagano Y, Narushima S, Suda W, Imaoka A, Setoyama H, Nagamori T, Ishikawa E, Shima T, Hara T, Kado S, Jinnohara T, Ohno H , Kondo T, Toyooka K, Watanabe E, Yokoyama S, Tokoro S, Mori H, Noguchi Y, Morita H, Ivanov II, Sugiyama T, Nunez G, Camp JG, Hattori M, Umesaki Y, Honda K. Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells. Cell . 2015 Oct 8;163(2):367-80. doi: 10.1016/j.cell.2015.08.058. Epub 2015 Sep 24.

Taniguchi T, Miyauchi E, Nakamura S, Hirai M, Suzue K, Imai T, Nomura T, Handa T, Okada H, Shimokawa C, Onishi R, Olia A, Hirata J, Tomita H, Ohno H , Horii T, Hisaeda H. Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis. Sci Rep . 2015 Oct 27;5:15699. doi: 10.1038/srep15699.

Sugahara H, Odamaki T, Fukuda S, Kato T, Xiao JZ, Abe F, Kikuchi J, Ohno H.Probiotic Bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community. Sci Rep . 2015 Aug 28;5:13548. doi: 10.1038/srep13548.

Nakato G, Hase K, Ohno H . Distinct microRNA expression profiles in follicle-associated epithelium and villous epithelium. Genom Data . 2015 Jul 15;5:388-90. doi: 10.1016/j.gdata.2015.07.011. eCollection 2015 Sep.

Nakajima M, Arimatsu K, Kato T, Matsuda Y, Minagawa T, Takahashi N, Ohno H , Yamazaki K. Oral Administration of P. gingivalis Induces Dysbiosis of Gut Microbiota and Impaired Barrier Function Leading to Dissemination of Enterobacteria to the Liver. PLoS One . 2015 Jul 28;10(7):e0134234. doi: 10.1371/journal.pone.0134234. eCollection 2015.

Nishida A, Miyamoto H, Horiuchi S, Watanabe R, Morita H, Fukuda S, Ohno H , Ichinose S, Miyamoto H, Kodama H.Bacillus hisashii sp. nov., isolated from the caeca of gnotobiotic mice fed with thermophile-fermented compost. Int J Syst Evol Microbiol . 2015 Aug 12. doi: 10.1099/ijsem.0.000516. [Epub ahead of print]

Yoshihara M, Ohmiya H, Hara S, Kawasaki S; FANTOM consortium., Hayashizaki Y, Itoh M, Kawaji H, Tsujikawa M, Nishida K.Discovery of molecular markers to discriminate corneal endothelial cells in the human body. PLoS One . 2015 Mar 25;10(3):e0117581. doi: 10.1371/journal.pone.0117581. eCollection 2015.

Matsumura T, Sugawara Y, Yutani M, Amatsu S, Yagita H, Kohda T, Fukuoka S, Nakamura Y, Fukuda S, Hase K, Ohno H , Fujinaga Y. Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity. Nat Commun . 2015 Feb 17;6:6255. doi: 10.1038/ncomms7255.

Kimura S, Yamakami-Kimura M, Obata Y, Hase K, Kitamura H, Ohno H , Iwanaga T. Visualization of the entire differentiation process of murine M cells: suppression of their maturation in cecal patches. Mucosal Immunol . 2015 May;8(3):650-60. doi: 10.1038/mi.2014.99. Epub 2014 Oct 22

Liang C; FANTOM Consortium., Forrest AR, Wagner GP.The statistical geometry of transcriptome divergence in cell-type evolution and cancer. Nat Commun . 2015 Jan 14;6:6066. doi: 10.1038/ncomms7066.

2014年

Yanagihara S, Goto H, Hirota T, Fukuda S, Ohno H , Yamamoto N. Lactobacillus acidophilus L-92 Cells Activate Expression of Immunomodulatory Genes in THP-1 Cells. Biosci Microbiota Food Health . 2014;33(4):157-64. doi: 10.12938/bmfh.33.157. Epub 2014 Aug 1.

Obata Y, Kimura S, Nakato G, Iizuka K, Miyagawa Y, Nakamura Y, Furusawa Y, Sugiyama M, Suzuki K, Ebisawa M, Fujimura Y, Yoshida H, Iwanaga T, Hase K, Ohno H . Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues. EMBO Rep . 2014 Dec;15(12):1297-304. doi: 10.15252/embr.201438942. Epub 2014 Nov 5.

Obata Y, Furusawa Y, Endo TA, Sharif J, Takahashi D, Atarashi K, Nakayama M, Onawa S, Fujimura Y, Takahashi M, Ikawa T, Otsubo T, Kawamura YI, Dohi T, Tajima S, Masumoto H, Ohara O, Honda K, Hori S, Ohno H , Koseki H, Hase K. The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells. Nat Immunol . 2014 Jun;15(6):571-9. doi: 10.1038/ni.2886. Epub 2014 Apr 28.

Honjo K, Kubagawa Y, Suzuki Y, Takagi M, Ohno H , Bucy RP, Izui S, Kubagawa H. Enhanced auto-antibody production and Mott cell formation in FcμR-deficient autoimmune mice. Int Immunol . 2014 Dec;26(12):659-72. doi: 10.1093/intimm/dxu070. Epub 2014 Jul 3.

Hasegawa Y, Tang D, Takahashi N, Hayashizaki Y, Forrest AR; FANTOM Consortium., Suzuki H. CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes. Sci Rep . 2014 Jun 24;4:5228. doi: 10.1038/srep05228. Erratum in: Sci Rep. 2014;4:6385.

Bubier JA, Jay JJ, Baker CL, Bergeson SE, Ohno H , Metten P, Crabbe JC, Chesler EJ. Identification of a QTL in Mus musculus for alcohol preference, withdrawal, and Ap3m2 expression using integrative functional genomics and precision genetics. Genetics . 2014 Aug;197(4):1377-93. doi: 10.1534/genetics.114.166165. Epub 2014 Jun 11.

Shima H, Watanabe T, Fukuda S , Fukuoka S, Ohara O, Ohno H . A novel mucosal vaccine targeting Peyer's patch M cells induces protective antigen-specific IgA responses. Int Immunol . 2014 Nov;26(11):619-25. doi: 10.1093/intimm/dxu061. Epub 2014 Jun 7.

Furusawa Y, Endo TA, Obata Y, Ohara O, Ohno H , Hase K . Pitfalls in global normalization of ChIP-seq data in CD4(+) T cells treated with butyrate: A possible solution strategy. Genom Data . 2014 Jun 27;2:176-80. doi: 10.1016/j.gdata.2014.06.018. eCollection 2014 Dec.

Kato T, Fukuda S , Fujiwara A, Suda W, Hattori M, Kikuchi J, Ohno H . Multiple omics uncovers host-gut microbial mutualism during prebiotic fructooligosaccharide supplementation. DNA Res . 2014 Oct;21(5):469-80. doi: 10.1093/dnares/dsu013. Epub 2014 May 19.

Obata Y, Kimura S, Nakato G, Iizuka K, Miyagawa Y, Nakamura Y, Furusawa Y, Sugiyama M, Suzuki K, Ebisawa M, Fujimura Y, Yoshida H, Iwanaga T, Hase K , Ohno H . Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues. EMBO Rep . 2014 Dec;15(12):1297-304. doi: 10.15252/embr.201438942. Epub 2014 Nov 5.

Nagasawa Y, Iio K, Fukuda S , Date Y, Iwatani H, Yamamoto R, Horii A, Inohara H, Imai E, Nakanishi T, Ohno H , Rakugi H, Isaka Y. Periodontal disease bacteria specific to tonsil in IgA nephropathy patients predicts the remission by the treatment. PLoS One . 2014 Jan 28;9(1):e81636. doi: 10.1371/journal.pone.0081636. eCollection 2014.

Date Y, Nakanishi Y, Fukuda S, Nuijima Y, Kato T, Umehara M, Ohno H , Kikuchi J. In vitro evaluation method for screening of candidate prebiotic foods. Food Chem . 2014;152:251-60. doi: 10.1016/j.foodchem.2013.11.126. Epub 2013 Dec 1.

Hanazato M, Nakato G, Nishikawa F, Hase K, Nishikawa S, Ohno H . Selection of an aptamer against mouse GP2 by SELEX. Cell Struct Funct . 2014;39(1):23-9. Epub 2013 Dec 12.

2013年

Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, Takahashi M, Fukuda NN, Murakami S, Miyauchi E, Hino S, Atarashi K, Onawa S, Fujimura Y, Lockett T, Clarke JM, Topping DL, Tomita M, Hori S, Ohara O, Morita T, Koseki H, Kikuchi J, Honda K, Hase K , Ohno H . Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature . 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.

Hase K1, Nakatsu F, Ohmae M, Sugihara K, Shioda N, Takahashi D, Obata Y, Furusawa Y, Fujimura Y, Yamashita T, Fukuda S, Okamoto H, Asano M, Yonemura S, Ohno H .AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice. Gastroenterology. 2013 Sep;145(3):625-35

Mandai Y1, Takahashi D, Hase K, Obata Y, Furusawa Y, Ebisawa M, Nakagawa T, Sato T, Katsuno T, Saito Y, Shimaoka T, Yokosuka O, Yokote K, Ohno H.　Distinct Roles for CXCR6+ and CXCR6- CD4+ T Cells in the Pathogenesis of Chronic Colitis. PLoS One . 2013 Jun 19;8(6):e65488

2012年

Nakato G , Hase K, Suzuki M, Kimura M, Ato M, Hanazato M, Tobiume M, Horiuchi M, Atarashi R, Nishida N, Watarai M, Imaoka K, Ohno H. Cutting Edge:Brucella abortus Exploits a Cellular Prion Protein on Intestinal M Cells as an Invasive Receptor.J Immunol . 2012 Jul 6. [Epub ahead of print]

Kanaya T , Hase K, Takahashi D, Fukuda S, Hoshino K, Sasaki I, Hemmi H, Knoop KA, Kumar N, Sato M, Katsuno T, Yokosuka O, Toyooka K, Nakai K, Sakamoto A, Kitahara Y, Jinnohara T, McSorley SJ, Kaisho T, Williams IR, Ohno H. The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells. Nat Immunol . 2012 Jun 17. doi: 10.1038/ni.2352. [Epub ahead of print]

Obata Y , Takahashi D, Ebisawa M, Kakiguchi K, Yonemura S, Jinnohara T, Kanaya T, Fujimura Y, Ohmae M, Hase K, Ohno H
Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis. J Immunol . 2012 Mar 1;188(5):2427-36. Epub 2012 Jan 25.

2011年

Nakanishi Y, Fukuda S, Chikayama E, Kimura Y, Ohno H, Kikuchi J.
Dynamic Omics Approach Identifies Nutrition-Mediated Microbial Interactions. J Proteome Res. 2011 Feb 4;10(2):824-836. Epub 2010 Dec 20.

Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DL, Suzuki T, Taylor TD, Itoh K, Kikuchi J, Morita H, Hattori M, Ohno H.
Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature. 2011 Jan 27;469(7331):543-7.

Ito M, Kitamura H, Kikuguchi , Hase K, Ohno H, Ohara O.
SP600125 inhibits cap-dependent translation independently of the c-Jun N-terminal kinase pathway. Cell Struct Funct. 2011 Jan 20.

2010年

Morita H, Nakano A, Onoda H, Toh H, Oshima K, Takami H, Murakami M, Fukuda S, Takizawa T, Kuwahara T, Ohno H, Tanabe S, Hattori M.
Bifidobacterium kashiwanohense sp. nov., isolated from healthy infant faeces. Int J Syst Evol Microbiol.2010 Dec 10.

Shima H, Takatsu H, Fukuda S, Ohmae M, Hase K, Kubagawa H, Wang JY, Ohno H.
Identification of TOSO/FAIM3 as an Fc receptor for IgM. Int Immunol. 2010 Mar;22(3):149-56. Epub 2009 Dec 30.

Date Y, Nakanishi Y, Fukuda S, Kato T, Tsuneda S, Ohno H, Kikuchi J.
New monitoring approach for metabolic dynamics in microbial ecosystems using stable-isotope-labeling technologies. J Biosci Bioeng. 2010 Jul;110(1):87-93. Epub 2010 Jan 27.

Ohno H, Hase K, Kimura S
M-Sec: Emerging secrets of tunneling nanotube formation. Commun Integr Biol. 2010 May;3(3):231-3.

2009年

Hase K, Kimura S, Takatsu H, Ohmae M, Kawano S, Kitamura H, Ito M, Watarai H, Hazelett CC, Yeaman C, Ohno H.
M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex. Nat Cell Biol . 2009 Dec;11(12):1427-32. Epub 2009 Nov 22.

Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K, Tobe T, Fujimura Y, Kawano S, Yabashi A, Waguri S, Nakato G, Kimura S, Murakami T, Iimura M, Hamura K, Fukuoka S, Lowe AW, Itoh K, Kiyono H, Ohno H.
Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response. Nature. 2009 Nov 12;462(7270):226-30.

Nakato G, Fukuda S, Hase K, Goitsuka R, Cooper MD, Ohno H.
New approach for m-cell-specific molecules screening by comprehensive transcriptome analysis. DNA Res . 2009 Aug;16(4):227-35.

Fukuda, S., Nakanishi, Y., Chikayama, E., Ohno, H. , Hino, T., Kikuchi, J.
Evaluation and characterization of bacterial metabolic dynamics with a novel profiling technique, real-time metabolotyping. PLoS ONE 4: e4893, 2009

Sugiura, Y., Nakatsu, F., Hiroyasu, K., Ishi, A., Hirose, S., Okada, M., Jibiki, I, Ohno, H., Kaneko, S., Ugawa, Y.
Lack of potassium current in W309R mutant KCNQ3 channel causing benign familial neonatal convulsions (BFNC). Epilepsy Res. 84 (1:): 82-85, 2009

2008年

Zhu, G., Okada, M., Yoshida, S., Ieno, S., Mori, F., Takahara, T., Saito, RR., Miura, Y., Kishi, A., Tomiyama, M., Sato, A., Kojima, T., Fukuma, G., Wakabayashi, K., Hase, K., Ohno, H ., Kijima, H., Takano, Y., Mitsudome, A., Kaneko, S., Hirose, S.
Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype. J. Neurosci. 28 (8): 12465-12476, 2008.

Hase K, Takahashi D, Ebisawa M, Kawano S, Itoh K, Ohno H.
Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease. PLoS ONE . 2008 Aug 21; 3 ( 8 ): e3033.

Kamijuku, H., Nagata, Y., Jiang, X., Ichinohe, T., Tashiro, T., Mori, K., Taniguchi, M., Hase, K., Ohno, H. , Shimaoka, T., Yonehara, S., Odagiri, T., Tahiro, M., Sata, T., Hasegawa, H., Seino, K-i.
Mechanism of NKT cell activation by intranasal coadministration of a -galactosylceramide, which can induce cross-protection against influenza. Mucosal Immunol. 1(3): 208-218, 2008

Terahara, K.*, Yoshida, M.*, Igarashi, O., Nochi, T., Pontes, G. S., Hase, K., Ohno, H. , Kurokawa, S., Mejima, M., Takayama, N., Yuki, Y., Lowe, A. W., Kiyono, H.
Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J. Immunol. 180 (12): 7840-7846, 2008(*First two authors contributed equally to this work.)

Morita, H., Toh, H., Fukuda, S., Horikawa, H., Oshima, K., Suzuki, T., Murakami, M., Hisamatsu, S., Kato, Y., Takizawa, T., Fukuoka, H., Yoshimura, T., Itoh, K., O'Sullivan, D. J., McKay, L. L., Ohno, H. , Kikuchi, J., Masaoka, T., Hattori, M.
Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production. DNA Res. 15 (3): 151-161, 2008

2007年

Kawano K, Ebisawa M, Hase K, Fukuda S, Hijikata A, Kawano S, Date Y, Tsuneda S, Itoh K, Ohno H.
Psg18 is specifically expressed in follicle-associated epithelium. Cell Struct Funct . 2007; 32 ( 2 ): 115-26 . Epub 2007 Nov 5.

Murakami T, Chen X, Hase K, Sakamoto A, Nishigaki C, Ohno H.
Splenic CD19-CD35+B220+ cells function as an inducer of follicular dendritic cell network formation. Blood . 2007 Aug 15; 110 ( 4 ): 1215-24 . Epub 2007 May 22.

Huang, M. C., Okada, M., Nakasu, F., Oguni, H., Ito, M., Morita, K., Nagafuji, H., Hirose, S., Sasaki, Y., Kaneko, S., Ohno, H. , Kojima, T.
Mutation screening of AP3M2 in Japanese epilepsy patients. Brain Dev. 29(8): 462-467, 2007

Hijikata, A., Kitamura, H., Kimura, Y., Yokoyama, R., Aiba, Y., Bao, Y., Fujita, S., Hase, K., Hori, S., Ishii, Y., Kanagawa, O., Kawamoto, H., Kawano, K., Koseki, H., Kibo, M., Kurita-Miki, A., Kurosaki, T., Masuda, K., Nakata, M., Oboki, K., Ohno, H ., Okamoto, M., Okayama, Y., O-Wang, J., Saito, H., Saito, T., Sakuma, M., Sato, K., Seino, K., Setoguchi, R., Tamura, Y., Tanaka, M., Taniguchi, M., Taniuchi, I., Teng, A., Watanabe, T., Watarai, H., Yamasaki, S., Ohara, O.
Construction of an open-access database that integrates cross-reference information from the transcriptome anda proteome of immune cells. Bioinformatics 23(21): 2934-2941, 2007

2006年

Fujimoto M, Takatsu H, Ohno H.
CMRF-35-like molecule-5 constitutes novel paired receptors, with CMRF-35-like molecule-1, to transduce activation signal upon association with FcRgamma.
Int Immunol . 2006 Oct; 18 ( 10 ): 1499-508 . Epub 2006 Aug 28.

Hase K, Murakami T, Takatsu H, Shimaoka T, Iimura M, Hamura K, Kawano K, Ohshima S, Chihara R, Itoh K, Yonehara S, Ohno H.
The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT. J Immunol . 2006 Jan 1; 176 ( 1 ): 43-51.

Takano-Maruyama, M., Hase, K., Fukamachi, H., Kato, Y., Koseki, H., Ohno, H .
Foxl1-deficient mice exhibit aberrant epithelial cell positioning due to dysregulated EphB/EphrinB in the small intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 291(1): G163-G170, 2006

Luo, H., Nakatsu, F., Furuno, A., Kato, H., Yamamoto, A., Ohno, H .
Visualization of the post-Golgi trafficking of multi-photon photoactivated transferrin receptors. Cell Struct. Funct . 31: 63-75, 2006

2005年


Mitsunari, T. Nakatsu, F., Shioda, N., Love, P.E., Grinberg, A., Bonifacino, J.S., Ohno, H.
Clathrin adaptor AP-2 is essential for early embryonal development. Mol. Cell. Biol. 25 (21): 9318-9323, 2005.

Hase, K., Ohshima, S., Kawano, K., Hashimoto, N., Matsumoto, K., Saito, H., Ohno, H.
Distinct gene expession profiles characterize cellular phenotypes of follicle-associated epithelium and M cells. DNA Res. 12 (2): 127-137, 2005.

2004年

Nakatsu F, Okada M, Mori F, Kumazawa N, Iwasa H, Zhu G, Kasagi Y, Kamiya H, Harada A, Nishimura K, Takeuchi A, Miyazaki T, Watanabe M, Yuasa S, Manabe T, Wakabayashi K, Kaneko S, Saito T, Ohno H.
Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor. J Cell Biol. 167(2):293-302.2004.

Kato, Y., Fukamachi, H., Takano-Maruyama, M., Aoe, T., Murahashi, Y., Horie, S., Suzuki, Y., Saito, Y., Koseki, H., Ohno H.
Reduction of SNAP25 in acid secretion defect of Foxl1 -/- g a stric parietal cells.Biochem. Biophys. Res. Commun. 320(3): 766-772, 2004.

Ito, M., Iidawa, S., Izuka, M., Haito, S., Segawa, H., Kuwahata, M., Ohkido, I., Ohno, H ., Miyamoto K.
Intreaction of a farnesylated protein with renal type IIa Na/Pi cotransporter in response to parathyroid hormone and dietary phosphate.
Biochem. J. 377: 607-616, 2004 .

Yoshimura, S., Yamamoto, A., Misumi, Y., Sohda, M., Barr, F. A., Fujii, G., Shakoori, A., Ohno, H. , Mihara, K., Nakamura, N.
Dynamics of Golgi matrix proteins after the blockage of ER to Golgi transport. J. Biochem. 135(2): 201-216, 2004.

2003年

Shakoori, A., Fujii, G., Yoshimura, S., Kitamura, M., Nakayama, K., Ito, T., Ohno, H. , Nakamura, N.
Identification of a five-pass transmembrane protein family localizing in the Golgi apparatus and the ER. Biochem. Biophys. Res.Commun. 312(3): 850-857, 2003.

Ohno, H.
Membrane traffic in the post-Golgi network: toward a better understanding of the higher order functioning systems. Cell Struct. Funct. 28: 396-397, 2003.

Nakatsu, F., Ohno, H.
The adaptor protein complex: A key regulators of protein sorting in post-Golgi network. Cell Struct. Funct. 28: 419-429, 2003.

2002年
Nishimura, K., Nakatsu, F., Kashiwagi, K., Ohno, H ., Saito, T., Igarashi K.
Essential role of S-adenosylmethionine decarboxylase in mouse embryonic development. Genes Cells 7(1):41-47, 2002

Nakamichi, N., Ohno, H , Kuramoto, N., Yoneda, Y.
Dual mechanisms of Ca 2+ increases elicited by N-methyl-D-aspartate in immature and mature cultured cortical neurons. J. Neurosci. Res. 67(2): 275-283, 2002.

Eskelinen, E.-L., Meyer, C., Ohno H., von Figura, K., Schu, P.
The polarized epithelia specific m 1B-adaptin complements m 1A-deficiency in fibroblasts. EMBO R eport 3(5): 471-477, 2002 .

Sugimoto, H., Sugahara, M., Folsch, H., Koide, Y., Nakatsu, F., Tanaka, N., Nishimura, T., Furukawa, M., Mullins, C., Nakamura, N., Mellman, I., Ohno, H.
Differential recognition of tyrosine-based basolateral signals by the AP-1B subunit m 1B in polarized epithelial cells. Mol. Biol. Cell 13(7): 2374-2382, 2002

Nakamichi N, Ohno H , Nakamura Y, Hirai T, Kuramoto N, Yoneda Y.
Blockade by ferrous iron of Ca2+ influx through N-methyl-d-aspartate receptor channels in immature cultured rat cortical neurons. J . Neurochem. 83(1): 1-11, 2002

Fu kamachi, K., Matsuoka, Y., Ohno, H ., Hamaguchi, T., Tsuda, H.
Neuronal leucine-rich repeat protein-3 amplifies MAP kinase activation by EGF through a carboxyl-terminal region containing endocytosis motifs. J. Biol. Chem. 277(46): 43549- 435 52 , 2002

Tabuchi, M., Tanaka, N., Nishida-Kitayama, J., Ohno, H., Kishi, F.
Alternative splicing regulates the subcellular localization of divalent metal ion transporter 1 isoforms. Mol. Biol. Cell 13(12): 4371- 43 87 , 2002

2001年
Arase, H., Suenaga, T., Arase, N., Kimura, Y., Ito, K., Shiina, R., Ohno, H . and Saito, T.
Negati v e regulation of expression and function of Fc g RIII by CD3 z in murine NK cells. J. Immunol .  166(1): 21-25, 2001.

Aguilar, R. C., Boehm, M., Gorshkova, I., Crouch, R. J., Tomita, K., Saito, T., Ohno, H.
and Bonifacino, J. S.: Signal-binding specificity of the m 4 subunit of the adaptor protein complex, AP-4. J. Biol. Chem . 276(16): 13145-13152, 2001.

Tomita, K., Saijo, K., Yamasaki, S., Iida, T., Nakatsu, F., Arase, H., Ohno, H ., Shirasawa, T., Kuriyama, T., O'Shea, J. J. and Saito, T.
Cytokine-independent Jak3 activation upon TCR stimulation through direct association of Jak3 and the TCR complex. J. Biol. Chem . 276(27): 25378-25385, 2001.

Ohka, S., Ohno, H ., Tohyama, K., and Nomoto, A.
Basolateral sorting of human poliovirus receptor a involves an interaction with the m 1B subunit of the clathrin adaptor complex in polarized epithelial cells. Biochem. Biophys. Res. Commun. 287(4):941-948, 2001.

Blumstein , J. , Faundez, V., Nakatsu, F., Saito, T., Ohno, H ., Kelly, R. B.
The neuronal form of AP-3 is required for synaptic vesicle formation from endosomes. J. Neurosci. 21(20): 8034-8042, 2001 .

Yoshimura, S., Nakamura, N., Barr, F. A., Misumi, Y., Ikehara, Y., Ohno, H ., Sakaguchi, M., Mihara, K.
Direct targeting of GM130, a cis-Golgi matrix protein, to the Golgi apparatus. J. Cell Sci . 114(Pt22): 4105-4115, 2001.

2000年
Nakatsu, F., Sakuma, M., Matsuo, Y., Arase, H., Yamasaki, S., Nakamura, N., Saito, T., Ohno, H .
A di-leucine signal in the ubiquitin moiety: possible involvement in ubiquitination-mediated endocytosis. J. Biol. Chem. 275(34): 26213-26219, 2000.

Kuno, K., Okada, Y., Kawashima, H., Nakamura, H., Miyasaka, M., Ohno, H ., Matsushima, K.
ADAMTS-1 cleaves a cartilage proteoglycan, aggrican. FEBS Lett . 478(3): 241-245, 2000.

Okazaki, Y., Ohno, H ., Takase, K., Ochiai, T. and Saito, T.
Cell surface expression of calnexin, a molecular chaperone in the endoplasmic reticulum.  J. Biol. Chem . 275(46): 35751-35758, 2000.

1999年
Ohno, H ., Tomemori, T., Nakatsu, F., Okazaki, Y., Aguilar, R. C., Foelsch, H., Mellman, I., Saito, T., Shirasawa, T., Bonifacino, J.S.
m 1B: a novel adaptor medium chain expressed in polarized epithelial cells. FEBS Lett. 449(2-3): 215-220, 1999.

Wild, M. K., Cambiaggi, A., Brown, M. H., Davies, E. A., Ohno, H. , Saito, T., van der Merwe, P. A.
Dependence of T cell antigen recognition on the dimensions of and accessory receptor-ligand complex. J. Exp. Med. 190(1): 31-41 ， 1999.

Nakaseko C, Miyatake S, Iida T, Hara S, Abe R, Ohno H , Saito T.
Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tail. J. Exp. Med. 190(6): 765-774, 1999.

Folsch, H., Ohno, H. , Bonifacino, J. S., Mellman, I.
A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. Cell 99(2): 189-198, 1999.

Watanabe, N., Akikusa, B., Park, S. Y., Ohno, H ., Fossati, L., Vecchietti, G., Gessner, J. E., Schmidt, R. E., Verbeek, J. S., Ryffel, B., Iwamoto, I., Izui, S., Saito, T.
Mast cells induce autoantibody-mediated vasculitis syndrome through tumor necrosis factor production upon triggering Fc g receptors. Blood 94(11): 3855-3863, 1999.

Nakatsu, F., Kadohira, T., Gilbert, D. J., Jenkins, N. A., Kakuda, H., Copeland, N. G., Saito, T., Ohno, H.
Genomic structure and chromosomal mapping of the genes encoding clathrin-associated adaptor medium chains m 1A (Ap1m1) and m 1B (Ap1m2). Cytogenet. Cell Genet. 87(1-2): 53-58, 1999.

1998年以前