発表論文一覧

原著（欧文　和文）　　総説（欧文　和文）　　単行書（欧文　和文）

原著論文

　　欧文

  1. Ohno, H., Watanabe, M., Saitoh, J., Saegusa, Y., Hasegawa, Y., Yonezawa, T.  Effect of epinephrine concentration on lidocaine disposition during epidural anesthesia. Anesthesiology 68: 625-628, 1988.
  2. Kuraishi, Y., Nanayama, T., Ohno, H., Minami, M., Satoh, M. Antinociception induced in rats by intrathecal administration of antiserum against calcitonin gene-related peptide. Neurosci. Lett. 92: 325-329, 1988.
  3. Ohno, H., Kuraishi, Y., Minami, M., Satoh, M. Modality-specific antinociception produced by intrathecal injection of anti-somatostatin antiserum in rants. Brain Res. 474: 197-200, 1988.
  4. Kuraishi, Y., Nanayama, T., Ohno, H., Fujii, N., Otaka, A., Yajima H., Satoh, M. Calcitonin gene-related peptide increases in the dorsal root ganglia of adjuvant arthritic rat. Peptides 10: 447-452, 1989.
  5. Nanayama, T., Kuraishi, Y., Ohno, H., Satoh, M. Capsaicin-induced release of calcitonin gene-related peptide from dorsal horn slices is enhanced in adjuvant arthritic rats. Neurosci. Res. 6: 569-572, 1989.
  6. Ohno, H., Kuraishi, Y., Nanayama, T., Minami, M., Kawamura, M., Satoh, M. Somatostatin is increased in the dorsal root ganglia of adjuvant-inflamed rat. Neurosci. Res. 8: 179-188, 1990.
  7. Saito, T., Folkes, B.J., Pardoll, D., Ohno, H. A murine thymocyte clone expressing gd T cell receptor mediates NK-like cytolytic function and TH1-like lymphokine production. Cell. Immunol. 131: 284-301, 1990.
  8. Ohno, H., Saito, T. CD3z and h chains are produced by alternative splicing from a common gene. Int. Immunol. 2, 1117-1119, 1990.
  9. Ohno, H., Ushiyama, C., Taniguchi, M., Germain, R.N., Saito, T. CD2 can mediate TCR/CD3-independent T cell activation. J. Immunol. 146: 3742-3746, 1991.
  10. Ohno, H.., Nakamura, T., Yagita, H., Okumura, K., Taniguchi, M., Saito, T. Induction of ｧnegative signal through CD2 during antigen-specific T cell activation. J. Immunol. 147: 2100-2106, 1991.
  11. Aoe, T., Ohno, H.., Sonta, S., Saito, T. Functional inactivation of CD3z chain in a T cell hybridoma by in vitro gene targeting. Int. Immunol. 5: 725-733, 1993.
  12. Ohno, H., Aoe, T., Ra, C., Yamamoto, T., Saito, T. TCR isoform containing the Fc receptor g chain exhibits structural and functional differences from isoform containing CD3z. Int. Immunol. 5: 1403-1411, 1993.
  13. Ohno, H., Aoe, T., Taki, S., Kitamura, D., Ishida, Y., Rajewsky, K., Saito, T.  Developmental and functional impairment of T cells in mice lacking CD3z chains. EMBO J. 12: 4357-4366, 1993.
  14. Ohno, H., Ono, S., Hirayama, N., Shimada, S., Saito, T.  Preferential usage of the Fc Receptor g chain in the T cell antigen receptor complex by g/d T cells localized in epithelia. J. Exp. Med. 179: 365-369, 1994.
  15. Nakano, H., Ohno, H., Saito, T. Activation of phospholipase C-g 1 through transfected platelet-derived growth factor receptor enhances interleukin 2 production upon antigen stimulation in a T-cell line. Mol. Cell. Biol. 14: 1213-1219, 1994.
  16. Kuwabara, I., Ohno, H., Punt, J.A., Hashimoto, Y., Saito, T. Transition from TCRb dimer- to TCRab-expressing cells by introduction of an a chain in an immature thymocyte cell line. J. Immunol. 152: 2148-2156, 1994.
  17. Ohno, H., Goto, S., Taki, S., Shirasawa, T., Nakano, H., Miyatake, S., Aoe, T., Ishida, Y., Maeda, H., Shirai, T., Rajewsky, K., Saito, T. Targeted disruption of the CD3h locus causes high lethality in mice: Modulation of Oct-1 transcription on the opposite strand. EMBO J. 13: 1157-1165, 1994.
  18. Kojima, H., Shinohara, N., Hanaoka, S., Someya-Shirota, Y., Takagaki, Y., Ohno, H., Saito, T., Katayama, T., Yagita, H., Okumura, K., Shinkai, Y., Alt, F. W., Matsuzawa, A., Yonehara, S., Takayama, H. Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes. Immunity 1: 357-364, 1994.
  19. Aoe, T., Goto, S., Ohno, H., Saito, T. Different cytoplasmic structure of the CD3z family dimer modulates the activation signal and function of T cells. Int. Immunol. 6: 1671-1679, 1994.
  20. Ono, S., Ohno, H., and Saito, T.  Rapid turnover of the CD3z chain independent of the TCR-CD3 complex in normal T cells. Immunity 2: 639-644, 1995.
  21. Arase, H., Ono, S., Arase, N., Park, S. Y., Wakizaka, K., Watanabe, H., Ohno, H., Saito, T. Developmental arrest of NK1.1+ TCR-ab+ T cells and expansion of NK1.1+ TCR-gd+ T cell development in CD3z-deficient mice. J. Exp. Med. 182: 891-895, 1995.
  22. Ohno, H., Stewart, J., Fournier, M-C., Bosshart, H., Rhee, I., Miyatake, S., Saito, T., Gallusser, A., Kirchhausen, T., Bonifacino, J.S. Interaction of tyrosine-based sorting signals with the medium chains of clathrin-associated protein complexes. Science 269: 1872-1875, 1995.
  23. Aoe, T., Okamoto, Y., Arase, H., Ikuta, K., Miyazaki, J., Ono, S., Ohno, H., Miyatake, S. and Saito, T. Preferential requirement of CD3z-mediated signals for development of immature rather than mature thymocytes. Int. Immunol. 8: 1055-1066, 1996.
  24. Marks, M.S., Woodruff, L., Ohno, H., Bonifacino, J.S. Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components. J. Cell. Biol. 135: 341-354, 1996.
  25. Boll, W., Ohno, H., Songyang, Z., Rapoport, I., Cantley, L.C., Bonifacino, J.S. Kirchhausen, T. Minimal requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes. EMBO J. 21: 5789-5795, 1996. (First three authors contributed equally to this work.)
  26. Ohno, H., Fournier, M.-C., Poy, G., Bonifacino, J.S. Structural determinants of interaction of tyrosine-based sorting signals with the adaptor medium chains. J. Biol. Chem. 271: 29009-29015, 1996.
  27. Yamazaki, T., Arase, H., Ono, S., Ohno, H., Watanabe, H., Saito, T. A shift from negative to positive selection of autoreactive T cells by the reduced level of TCR signal in TCR-transgenic CD3z-deficient mice. J. Imunol. 158: 1634-1640, 1997.
  28. DellﾕAngelica, E.C., Ohno, H., Ooi, C. E., Rabinovich, E., Roche, C.W., Bonifacino, J. S. AP-3: an adaptor-like complex with ubiquitous expression.  EMBO J. 16: 917-928, 1997.
  29. Shiratori, T., Miyatake, S., Ohno, H., Nakaseko, C., Bonifacino, J.S., Saito, T. Tyrosine phosphorylation controls internalization of CTLA4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity 6: 583-589, 1997.
  30. Aguilar, R. C., Ohno, H., Roche, K. W., Bonifacino, J. S. Functional domain mapping of the clathrin-associated adaptor medium chains ｵ1 and ｵ2. J. Biol. Chem. 272: 27160-27166, 1997.
  31. Ohno, H., Aguilar, R. C., Fournier, M.-C., Hennecke, S., Cosson, P., Bonifacino, J. S. Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of adaptor medium chain family. Virology 238: 305-315, 1997.
  32. Arase, N., Arase, H., Park, S. Y., Ohno, H., Ra, C., Saito, T. Association with FcRg is essential for activation signal through NKR-P1 (CD161) in natural killer (NK) cells and NK1.1+ T cells. J. Exp. Med. 186: 1957-1963, 1997.
  33. Ohno, H., Poy G., Bonifacino, J. S. Cloning of the gene encoding the murine clathrin-associated adaptor medium chain ｵ2: gene organization, alternative splicing and chromosomal   assignment. Gene 210: 187-193, 1998.
  34. Park, S., Ueda, S., Ohno, H., Hamano, Y., Tanaka, M., Shiratori, T., Yamazaki, T., Arese, H., Arese, N., Karasawa, A., Sato, S., Ledermann, B., Kondo, Y., Okumura, K., RA, C., Saito, T. Resistance of Fc receptor-deficient mice to fatal glomerulonephritis. J. Clin. Invest. 102: 1229-1238, 1998.
  35. Ohno, H., Aguilar, R. C., Yeh, D., Taura, D., Saito, T., Bonifacino, J. S. The Medium Subunits of Clathrin Adaptor Complexes Recognize Distinct but Overlapping Sets of Tyrosine-based Sorting Signals. J. Biol. Chem. 273: 25915-25921, 1998.
  36. Ohno, H., Tomemori, T., Nakatsu, F., Okazaki, Y., Aguilar, R. C., Foelsch, H., Mellman, I., Saito, T., Shirasawa, T., Bonifacino, J.S. m1B: a novel adaptor medium chain expressed in polarized epithelial cells. FEBS Lett. 449: 215-220, 1999.
  37. Wild, M. K., Cambiaggi, A., Brown, M. H., Davies, E. A., Ohno, H., Saito, T., van der Merwe, P. A. Dependence of T cell antigen recognition on the dimensions of and accessory receptor-ligand complex. J. Exp. Med. 190: 31-41, 1999.
  38. Nakaseko C, Miyatake S, Iida T, Hara S, Abe R, Ohno H, Saito T: Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tail. J. Exp. Med. 190: 765-774, 1999.
  39. F嗟sch, H., Ohno, H., Bonifacino, J. S., Mellman, I. A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. Cell 99:189-198, 1999.
  40. Nakatsu, F., Kadohira, T., Gilbert, D. J., Jenkins, N. A., Kakuda, H., Copeland, N. G., Saito, T., Ohno, H. Genomic structure and chromosomal mapping of the genes encoding clathrin-associated adaptor medium chains m1A (Ap1m1) and m1B (Ap1m2). Cytogenet. Cell Genet. 87: 53-58, 1999.
  41. Nakatsu, F., Sakuma, M., Matsuo, Y., Arase, H., Yamasaki, S., Nakamura, N., Saito, T., Ohno, H. A di-leucine signal in the ubiquitin moiety: possible involvement in ubiquitination-mediated endocytosis. J. Biol. Chem. 275: 26213-26219, 2000.
  42. Kuno, K., Okada, Y., Kawashima, H., Nakamura, H., Miyasaka, M., Ohno, H., Maatsushima, K.: ADAMTS-1 cleaves a cartilage proteoglycan, aggrican. FEBS Lett. 478: 241-245, 2000.
  43. Iida, T., Ohno, H., Nakaseko, C., Sakuma, M., Takeda-Ezaki, M., Arase, H., Kominami, E., Fujisawa, T. and Saito, T.: Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells. J. Immunol. 165: 5062-5068, 2000.
  44. Okazaki, Y., Ohno, H., Takase, K., Ochiai, T. and Saito, T.: Cell surface expression of calnexin, a molecular chaperone in the endoplasmic reticulum.  J. Biol. Chem. 275: 35751-35758, 2000.
  45. Arase, H., Suenaga, T., Arase, N., Kimura, Y., Ito, K., Shiina, R., Ohno, H. and Saito, T.: Negatibe regulation of expression and functiton of FcRgRIII by CD3g in murine NK cells. J. Immunol. 166: 21-25, 2001.
  46. Aguilar, R. C., Boehm, M., Gorshkova, I., Crouch, R. J., Tomita, K., Saito, T., Ohno, H. and Bonifacino, J. S.: Signal-binding specificity of the m4 subunit of the adaptor protein complex, AP-4.  J. Biol. Chem. in press

    47.  


　　和文

  1. 三枝義信、渡辺誠、大野博司、長谷川洋機、川本健志、花輪浩一　高速液体クロマトグラフィーによるリドカイン及びその活性代謝産物の血中濃度モニタリングのための測定法の検討.　臨床病理　34: 1193-1197, 1986.
  2. 大野博司、河崎純忠、吉田豊　開胸術後の心房細動：統計学的検討.　日本臨床麻酔学雑誌　9: 69-74, 1989.


総説

　欧文

  1. Ohno, H., Kirchhausen, T. and Bonifacino, J. S. Recognition of Tyrosine-based sorting signals by the medium chains of clathrin-associated protein complexes. J. NIH Res. 7: 50-51, 1995.
  2. Bonifacino, J.S., Marks, M. S., Ohno, H. and Kirchhhausen, T. Mechanisms of signal-mediated protein sorting in the endocytic and secretory pathways. Proc. Assoc. Amr. Physicians 108: 285-295, 1996.
  3. Marks, M. S., Ohno, H., Kirchhausen, T. and Bonifacino, J. S. Protein sorting by tyrosine-based signals: Adapting to Y and wherefore. Trends Cell Biol. 7: 124-128, 1997.


　和文

  1. 斉藤隆、大野博司　リンパ球接着分子の機能.　細胞工学　8: 503-512, 1989.
  2. 大野博司、斉藤隆　Ｔ細胞レパトア形成の分子機構.　臨床免疫　22: 731-743, 1990.
  3. 大野博司、CD2-TCR/CD3相互作用.　臨床免疫　22: 1225-1232, 1990.
  4. 斉藤隆、大野博司　CD3複合体の新しい構成.　代謝　増刊号「免疫ﾕ91」　28: 77-85, 1991.
  5. 青江知彦、大野博司、斉藤隆　CD分子―マーカーから機能への展開　I　Ｔ細胞機能分子：CD3.　Medical Immunology　24: 409-417, 1992.
  6. 大野博司、斉藤隆　今日の臨床免疫　チロシンキナーゼを介したシグナル伝達Part2：Ｔ細胞受容体とチロシンリン酸化.　Medical Immunology　24: 117-125, 1992.
  7. 斉藤隆、大野博司、宮武昌一郎　Ｔ細胞抗原レセプターを介するシグナル伝達.　実験医学　10: 1755-1762, 1992.
  8. 大野博司　Ｔ細胞レセプターとシグナル伝達.　免疫・Immunology Frontier　2: 430-433, 1992.
  9. 大野博司　アレルギー領域における学会最新情報―アレルギー領域の進展―.　Therapeutic Research　13: 12-16, 1992.
  10. 大野博司　CD2を介する負のシグナル.　臨床免疫　23: 379-385, 1993.
  11. 大野博司　Ｔ細胞の分化および機能におけるz鎖の役割：遺伝子ターゲティングマウスを用いた解析.　免疫･Immunology Frontier　3: 355-362, 1993.
  12. 大野博司、斉藤隆　zファミリーの展開.　Medical Immunology　25: 5-10, 1993.
  13. 斉藤隆、大野博司、青江知彦　Ｔ細胞抗原レセプターに会合するシグナル伝達系―CD3z,fyn,lck欠損マウスによる解析.　実験医学　11: 2517-2524, 1993.
  14. 大野博司　Ｔ細胞分化とzファミリ−分子.　Medical Immunology　27: 43-52, 1994.
  15. 大野博司　T細胞レセプター複合体遺伝子変異マウス. 造血因子　6: 261-270,     1995.
  16. 斉藤隆、大野博司、青江知彦、朴承龍　Ｔ細胞レセプタ−関連分子のノックアウトマウス.　疾患モデル　11: 49-53, 1995.
  17. 斉藤隆、朴承龍、大野博司　Ｔ細胞レセプタ−複合体によるＴ細胞分化の調節　TCR複合体分子欠損マウスによる解析.　蛋白質核酸　酵素 40: 2097-2106, 1995.
  18. 大野博司　チロシンモチーフとアダプター複合体の結合による細胞内蛋白質輸送機構．実験医学　4: 565-568, 1996.
  19. 大野博司　分泌系およびエンドサイトーシスにおける蛋白質輸送機構. 蛋白質　核酸　酵素　42: 2072-2080, 1997.
  20. 大野博司　HIV感染とエンドサイトーシス．医学のあゆみ　189: 1013-1014, 1999.
  21. 大野博司　エンドサイトーシス．臨床免疫 32:726-732,1999.
  22. 大野博司　上皮細胞における膜タンパク質の選別輸送．生体の科学　51:147-152, 2000.
  23. 大野博司　極性細胞における形質膜への選別輸送．細胞工学　19:1002-1007, 2000.
  24. 大野博司　小胞輸送と細胞極性．細胞工学　19:1781-1786, 2000
  25. 大野博司　Lysosomal targeting．生体の科学　51:615, 2000.
  26. 大野博司　細胞内タンパク質選別輸送−AP複合体による制御．生化学　73:-, 2001.
  27. 大野博司　クラスリン．分子細胞治療　印刷中

    28.  


単行書

　欧文

  1. Saito, T., Arase, H., Arase, N., Miyatake, S., Nakaseko, C., Ohno, H., Park, S.-Y., Shiratori, T., Takase, K. And Yamazaki, T. Kinases and phosphatases. in Lymphocyte and neuronal signaling. Springer-Verlag, Tokyo, pp 80, 1997.
　和文
  1. 斉藤隆、大野博司、谷口克　T細胞ハイブリドーマのつくり方.　日本生化学会編、新生化学実験講座12：分子免疫学I.　免疫細胞・サイトカイン.　東京化学同人、東京、 pp141-147, 1989.
  2. 大野博司、斉藤隆　T, B細胞ハイブリドーマ・モノクローナル抗体の作製.　山田鈎一郎、大石道夫、谷口克編、最新動物細胞実験マニュアル.　エル・アイ・シイ、東京、pp 99-111, 1990.
  3. 大野博司、斉藤隆　CD3複合体-その構造、発現および機能. 菊池浩吉、矢田純一、奥村康編、Annual Review 免疫1992.　中外医学社、東京、pp 20-34, 1992.
  4. 大野博司　T細胞レセプター複合体とシグナル伝達.　菊池浩吉、矢田純一、奥村康編、Annual Review 免疫 1994.　中外医学社、東京、pp 1-11, 1994.
  5. 大野博司、斉藤隆　遺伝子欠損マウスを用いたTCR/CD3複合体分子の機能解析.　岸本忠三、多田富雄編、免疫1994-95.　中山書店、東京、pp 126137, 1994.
  6. 大野博司　遺伝子工学入門６　疾患モデル動物の作り方　２.ノックアウトマウス.　鎌田武信、小俣政男編、FOCUS消化器3.　消  化器疾患の分子生物学入門.　中山書店、東京、    pp 39-51, 1994.
  7. 大野博司　免疫系における細胞内タンパク輸送.　岸本忠三編、免疫1997-98.　中山書店、東京、pp 192-201, 1997.
  8. 大野博司　エンドサイトーシスとクラスリン被覆小胞.　米田悦啓、中野明彦編、細胞内物質輸送のダイナミズム.　シュプリンガー・フェアラーク東京、東京、 p125、1999.